Here's a two day loop we did that I really enjoyed:
Sept 2014 Two Day Maryland, Virginia, West Virginia mountain twisties loop
Ben Mendis and I did a two day, roughly 530 mile, loop through the mountains of Virginia, West Virginia, and Maryland.
Of note was Route 72 off 219 in West Virginia which is just this wicked little twisty, albeit rough and treacherous, little just over driveway sized road that carves it's way along a river canyon. "River Road" branches off of it and runs along the water at the base of the gorge which is where we found these just scenically beautiful camping spots right on the water.
Also of note was route 647 in Virginia at exit 27 on I66 which turned out to be a beautiful rolling country road through alternating forests and farms.
As usual, Route 33 in Virginia and West Virginia proved to be awesome and wonderfully twisty as did the northern section of 219 before it meets up with 50. 50 East is a faster road but one that also carves it's way through lush green forests and has some incredible views.